Clinical Immunology
Principles and Practice
By: Robert R. Rich, Thomas A. Fleisher, Harry W. Schroeder Jr., Cornelia M. Weyand, David B. Corry, Jennifer M. Puck
About This Book
Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. Provides new genetics content focused on data applications. Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. Summarizes promising research and development anticipated over the next 5-10 years with On the Horizon boxes and discussions of translational research. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
AI Overview
Title: Clinical Immunology: Principles and Practice
Authors: Robert R. Rich, Thomas A. Fleisher, Harry W. Schroeder Jr., Cornelia M. Weyand, David B. Corry, Jennifer M. Puck
Overview:
"Clinical Immunology: Principles and Practice" is a comprehensive textbook that covers the entire spectrum of immunology, from basic science to clinical applications. The book is designed to provide authoritative guidance on the latest advancements in immunology, making it a valuable resource for both students and practitioners in the field.
Key Themes:
Basic Immunology:
- The book begins with a detailed explanation of the principles of immune response, including the organization of the immune system, innate immunity, antigen receptor genes, and major histocompatibility complex (MHC) functions.
Host-Environmental Interactions:
- It delves into the interactions between the host and the environment, including human genomics, regulatory RNA in immunologic diseases, and immunometabolism.
Host Defenses to Infectious Agents:
- The book covers the immune system's defenses against infectious agents, including immunology of the skin and mucosal surfaces.
Clinical Applications:
- It includes comprehensive coverage of common and uncommon immunologic disorders, along with the latest immunologic research and clinical implications. This includes breakthrough immunotherapies such as immune checkpoint inhibitors, CAR T cells, and gene therapy using CRISPR.
New Chapters and Content:
- The 6th edition includes new chapters on COVID-19, immune responses, and the role of the immune system. It also addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and the pathogenesis of immunologic and inflammatory diseases.
Critical Reception:
The book is widely regarded as a trusted and authoritative resource in the field of immunology. It is praised for its comprehensive coverage of both basic science and clinical scenarios, making it an essential tool for confident tackling of challenging issues in immunology.
The 6th edition has been updated with extensive revisions reflecting rapidly expanding research and clinical advances. This has been well-received by both students and practitioners, providing them with the latest information on immunotherapies and molecular-based treatment protocols.
Overall, "Clinical Immunology: Principles and Practice" is a seminal work that offers a unique, comprehensive coverage of immunology, making it an indispensable resource for anyone seeking to understand the complexities of the immune system and its applications in clinical practice.