Neoantigens Generated by Individual Mutations and Their Role in Immunity and Immunotherapy

The book "Neoantigens Generated by Individual Mutations and Their Role in Immunity and Immunotherapy" is not a traditional book but rather a research topic compilation edited by Sebastian Kreiter and Mustafa Diken. It is a collection of articles and research papers published on the Frontiers platform, focusing on the latest advancements in understanding the immunological mechanisms of neoantigen-directed T-cell immunity and its applications in cancer immunotherapy.

Key Themes

1. Immunological Mechanisms of Neoantigens:

   • The book explores the mechanisms by which neoantigens, generated by individual mutations in tumor cells, are recognized by the immune system. It delves into the immunogenicity of these neoepitopes and their role in triggering T-cell responses.

2. Cancer Immunotherapy:

   • It discusses the clinical applications of neoantigens in cancer immunotherapy, including the use of immune checkpoint inhibitors and adoptive transfer of autologous TILs (tumor-infiltrating lymphocytes).

3. Individualized Vaccination and Therapy:

   • The book highlights ongoing clinical trials that demonstrate the feasibility of using unique mutations as targets for individualized vaccination or adoptive cell therapy in cancer patients.

4. Advancements in NGS and Bioinformatics:

   • It covers the improvements in Next-Generation Sequencing (NGS) methods and bioinformatic solutions for identifying and prioritizing immunogenic mutations, which are crucial for cancer immunotherapy.

Plot Summary

The compilation does not have a traditional narrative structure but rather presents a series of research articles and reviews. The content is organized around the central theme of neoantigens and their role in immunity and immunotherapy. Each article contributes to a comprehensive understanding of the field, covering various aspects from mechanistic studies to clinical applications.

Critical Reception

Since this is a research topic compilation rather than a traditional book, there is no single critical reception. However, the articles within the compilation have been viewed and downloaded extensively, indicating significant interest and relevance in the scientific community. The editors, Sebastian Kreiter and Mustafa Diken, are recognized experts in their field, which further underscores the credibility of the content.

Conclusion

"Neoantigens Generated by Individual Mutations and Their Role in Immunity and Immunotherapy" is a critical resource for researchers and clinicians interested in cancer immunology and therapy. It provides an up-to-date overview of the latest research and advancements in the field, making it a valuable contribution to the scientific literature.